Adam Buxton scored his first Stanley goal but AFC Wimbledon secured the three points.
Sean Rigg rifled home the opener for the Dons on 37 minutes and then sub Adebayo Azeez grabbed a second 12 minutes from time.
Buxton got a goal back for the Reds in the 88th minute in his first appearance since the early games of the season but Stanley couldn’t grab the equaliser.
John Coleman brought back Michael Liddle and Anthony Barry into the side after the 3-0 loss to Tranmere.
But it was the Dons were lively early on with Ade Akinfenwa having an effort saved by Matt Macey while Danny Bulman’s low strike from the edge of the box cannoned off the post in the eighth minute.
The game was played out in midfield for large periods with Kal Naismith’s creating Stanley’s first real chance, with his 20-yard effort narrowly over the bar in the 23rd minute.
Naismith had the next chance, which didn’t come until 10 minutes later, when he forced Dons keeper Shea into the first real action, diving to push away his 30 yard curling strike.
However Wimbledon then made a chance count on 37 minutes. On loan Reading star Craig Tanner had his effort superbly pushed away by Arsenal loan keeper Macey but Rigg reacted first to fire home the opener.
And they came close to a second minutes later when Tanner broke clean through on the left but Macey again reacted well to deny him.
Just before half-time, Stanley forced a succession of corners but couldn’t capitalise and, from one, Wimbledon broke quickly as they looked for a two-goal half-time cushion but thankfully Liddle got back to clear Barry Fuller’s cross.
After the break, Stanley needed to battle back and they came close when , after good build-up play, the ball came to Anthony Barry on 55 minutes. The midfielder rifled the ball goalwards with a combination of the woodwork and keeper Shea denying the Reds a leveller.
Coleman was the first to make a change, bringing on James Gray for Maguire on the hour mark before, shortly after, Josh Windass replaced Andy Procter.
Stanley were then the more dominant team with a cross by skipper Joyce just failing to find Gray – who has good record with three goals in the last two games against the Dons.
Boss Neal Ardley then made a double substitution on 73 minutes and it needed another swift reaction from Macey to keep out Fuller’s blast.
And they then got the important second on 78 minutes when George Francomb battled for the ball on the right and fed in sub Azeez who fired past Macey.
Azeez should have had a third moments later when he burst through – although there was the suspicion of off-side – but he scuffed his final effort into Macey’s grateful arms.
And Stanley got what proved a consolation when Naismith’s cross wasn’t held onto by Shea and Buxton poked the ball home.
But it wasn’t enough and it was a second successive loss for the Reds.